Content-Centric Networking at Internet Scale through The Integration of Name Resolution and Routing

We introduce CCN-RAMP (Routing to Anchors Matching Prefixes), a new approach to content-centric networking. CCN-RAMP offers all the advantages of the Named Data Networking (NDN) and Content-Centric Networking (CCNx) but eliminates the need to either use Pending Interest Tables (PIT) or lookup large Forwarding Information Bases (FIB) listing name prefixes in order to forward Interests. CCN-RAMP uses small forwarding tables listing anonymous sources of Interests and the locations of name prefixes. Such tables are immune to Interest-flooding attacks and are smaller than the FIBs used to list IP address ranges in the Internet. We show that no forwarding loops can occur with CCN-RAMP, and that Interests flow over the same routes that NDN and CCNx would maintain using large FIBs. The results of simulation experiments comparing NDN with CCN-RAMP based on ndnSIM show that CCN-RAMP requires forwarding state that is orders of magnitude smaller than what NDN requires, and attains even better performance

NDN, CoAP, and MQTT: A Comparative Measurement Study in the IoT

This paper takes a comprehensive view on the protocol stacks that are under debate for a future Internet of Things (IoT). It addresses the holistic question of which solution is beneficial for common IoT use cases. We deploy NDN and the two popular IP-based application protocols, CoAP and MQTT, in its different variants on a large-scale IoT testbed in single- and multi-hop scenarios. We analyze the use cases of scheduled periodic and unscheduled traffic under varying loads. Our findings indicate that (a) NDN admits the most resource-friendly deployment on nodes, and (b) shows superior robustness and resilience in multi-hop scenarios, while (c) the IP protocols operate at less overhead and higher speed in single-hop deployments. Most strikingly we find that NDN-based protocols are in significantly better flow balance than the UDP-based IP protocols and require less corrective actions

Chronic kidney disease increases the susceptibility to negative effects of low and high potassium intake

BackgroundDietary potassium (K+) has emerged as a modifiable factor for cardiovascular and kidney health in the general population, but its role in people with chronic kidney disease (CKD) is unclear. Here, we hypothesize that CKD increases the susceptibility to the negative effects of low and high K+ diets.MethodsWe compared the effects of low, normal and high KChloride (KCl) diets and a high KCitrate diet for 4 weeks in male rats with normal kidney function and in male rats with CKD using the 5/6th nephrectomy model (5/6Nx).ResultsCompared with rats with normal kidney function, 5/6Nx rats on the low KCl diet developed more severe extracellular and intracellular K+ depletion and more severe kidney injury, characterized by nephromegaly, infiltration of T cells and macrophages, decreased estimated glomerular filtration rate and increased albuminuria. The high KCl diet caused hyperkalemia, hyperaldosteronism, hyperchloremic metabolic acidosis and severe hypertension in 5/6Nx but not in sham rats. The high KCitrate diet caused hypochloremic metabolic alkalosis but attenuated hypertension despite higher abundance of the phosphorylated sodium chloride cotransporter (pNCC) and similar levels of plasma aldosterone and epithelial sodium channel abundance. All 5/6Nx groups had more collagen deposition than the sham groups and this effect was most pronounced in the high KCitrate group. Plasma aldosterone correlated strongly with kidney collagen deposition.ConclusionsCKD increases the susceptibility to negative effects of low and high K+ diets in male rats, although the injury patterns are different. The low K+ diet caused inflammation, nephromegaly and kidney function decline, whereas the high K+ diet caused hypertension, hyperaldosteronism and kidney fibrosis. High KCitrate attenuated the hypertensive but not the pro-fibrotic effect of high KCl, which may be attributable to K+-induced aldosterone secretion. Our data suggest that especially in people with CKD it is important to identify the optimal threshold of dietary K+ intake

Quantification and Qualification of Bacteria Trapped in Chewed Gum

Chewing of gum contributes to the maintenance of oral health. Many oral diseases, including caries and periodontal disease, are caused by bacteria. However, it is unknown whether chewing of gum can remove bacteria from the oral cavity. Here, we hypothesize that chewing of gum can trap bacteria and remove them from the oral cavity. To test this hypothesis, we developed two methods to quantify numbers of bacteria trapped in chewed gum. In the first method, known numbers of bacteria were finger-chewed into gum and chewed gums were molded to standard dimensions, sonicated and plated to determine numbers of colony-forming-units incorporated, yielding calibration curves of colony-forming-units retrieved versus finger-chewed in. In a second method, calibration curves were created by finger-chewing known numbers of bacteria into gum and subsequently dissolving the gum in a mixture of chloroform and tris-ethylenediaminetetraacetic-acid (TE)-buffer. The TE-buffer was analyzed using quantitative Polymerase-Chain-Reaction (qPCR), yielding calibration curves of total numbers of bacteria versus finger-chewed in. Next, five volunteers were requested to chew gum up to 10 min after which numbers of colony-forming-units and total numbers of bacteria trapped in chewed gum were determined using the above methods. The qPCR method, involving both dead and live bacteria yielded higher numbers of retrieved bacteria than plating, involving only viable bacteria. Numbers of trapped bacteria were maximal during initial chewing after which a slow decrease over time up to 10 min was observed. Around 10(8) bacteria were detected per gum piece depending on the method and gum considered. The number of species trapped in chewed gum increased with chewing time. Trapped bacteria were clearly visualized in chewed gum using scanning-electron-microscopy. Summarizing, using novel methods to quantify and qualify oral bacteria trapped in chewed gum, the hypothesis is confirmed that chewing of gum can trap and remove bacteria from the oral cavity

Role of Dietary K+ in Natriuresis, Blood Pressure Reduction, Cardiovascular Protection, and Renoprotection

Nephrolog

Censored Young Adult Sports Novels: Entry Points for Understanding Issues of Identities and Equity

In early 2018, first-year high school student Ny’Shira Lundy challenged the banning of Angie Thomas’s (2017) young adult novel The Hate U Give, which for reasons of vulgarity, was temporarily removed from shelves in Katy, Texas. In February 2018, the more public and privileged National Basketball Association (NBA) players, LeBron James and Kevin Durant, were also challenged, this time by political talk show host Laura Ingraham, who reacted to the players’ unfavorable public comments about the President of the United States. “Must they run their mouths like that?” Ingraham (ingrahamangle, 2018) asked. “Unfortunately, a lot of kids—and some adults—take these ignorant comments seriously. And it’s always unwise to seek political advice from someone who gets paid a hundred million dollars a year to bounce a ball” (Bonesteel & Bieler, 2018). On social media, the hashtag #ShutUpAndDribble exploded

Pengantar kromatografi, ed. 2/ Gritter

266 hal. : ill. ; 21 cm